Christopher DeSimone

Christopher DeSimone

Dr. Christopher DeSimone, MD, PhD, is an Assistant Professor of Medicine at the Mayo Clinic Graduate School of Medicine. He completed his undergraduate studies at Niagara University and graduated Summa Cum Laude with University Honors with a Bachelors degree in Biochemistry, and a second Bachelors degree in Biology. He completed a Medical Scientist Training Program at the University at Buffalo School of Medicine and Biomedical Sciences. He obtained both his M.D. and a Ph.D. in Physiology, with a focus on the cellular and molecular cardiac electrophysiology of voltage-gated potassium channels. His doctoral dissertation on peptide-potassium channel interaction and gating mechanisms, earned the Dean’s Award for Outstanding thesis for the School of Medicine and Biomedical Sciences. He completed internship and residency at the Mayo Clinic Graduate School of Medicine.  He garnered the Outstanding Research Achievement award during his training. He was awarded an NIH training grant for a combined clinical and research fellowship in Cardiology in the Division of Cardiovascular Diseases at the Mayo Clinic. He was a fellow in the Cardiovascular Innovation lab under the mentorship of Dr. Samuel Asirvatham and Dr. Paul Friedman. He will be starting an advanced fellowship in Clinical Cardiac Electrophysiology in July 2017.

He has published over 70 manuscripts, 40 abstracts, and several book chapters. He has obtained multiple research grants for innovation as well as for the development of clinical trials with a special focus on stroke prevention in patients with implanted cardiac devices. He is heavily involved in the field of innovation and has filed several patents. His innovation focuses on development of novel tools and approaches in the field of cardiovascular electrophysiology. These encompass a wide range of innovative-ability which includes non-thermal based cardiac electroporation for novel catheter ablation for atrial fibrillation; novel approaches for autonomic ganglia modulation for atrial fibrillation ablation; development of a novel epicardial device system for pacing, defibrillation, and ablation; and novel approaches for ventricular fibrillation mapping and ablation.

His research is driven solely by his strong passion for continuously improving care of his patients. He is continuously questioning and re-assessing current medical practice with specific attention on gaps in knowledge or areas where patient care can be improved. He is extremely bothered when there are no good solutions or no therapies yet available to help improve the quality of life of his patients. This fuel his drive for research and results in many nights of deep thought where innovative ideas are generated which he hopes one day can serve as a solution to relieve suffering.